We will collect clinical, histological and radiological data, including delayed contrast MRI, from 400 women with breast lesions, to develop an advanced analysis platform for MRI-based blood vessel characterization in abnormal breast tissues. The resulting platform is expected to enable: 1) personalized diagnosis – differentiation between benign and malignant tissues for deciding whether to perform a biopsy and to plan biopsies; 2) personalized malignant lesion characterization, such as cancer type and grade; and 3) personalized assessment of response – differentiation of an active tumor from treatment-induced effects. In addition, a large, rapidly growing database of clinical, histological and MRI data of women with breast lesions will be created.