Ubiquitous in our lives, stress affects physical and mental wellbeing. The stress response is multi-layered biological and psychological, and changes through time. Individuals differ in how they react to stress, and there is no way to predict who is going to develop long-term psychopathology. Combining expertise in neuroscience, psychiatry, genetics, statistics, and artificial intelligence, the research team plans to develop a dynamic risk-prediction model for psychopathology, closely following a traumatic event, and for the development of psychological problems over time. The model will also guide early personalized interventions and improve long-term prognosis. It will provide the basis for similar developments in other psychopathologies in which unfolding in time is critical for characterization and treatment improvement.